Introducción
In the structure of cardiovascular diseases, the leading importance is given to chronic heart failure (CHF) due to the high risk of general and cardiovascular mortality. Patients with CHF have a large number of comorbid conditions affecting the immediate and long-term prognosis, among which rhythm disturbances, especially atrial fibrillation (AF), are of great importance. Objective. To evaluate some molecular genetic features of patients with chronic heart failure.

Materiales y Métodos
The study included 68 patients (36 men and 32 women), with an average age of 68.9 ± 9.5 years, who were admitted to the round-the-clock hospital of the Novosibirsk Regional Clinical Hospital of War Veterans No. 3 in the period from 10.01.2024 to 09.01.2024. with diagnosed CHF of stage I–III and FC I–IV. The diagnosis of chronic heart failure was verified in accordance with the current clinical recommendations of the Russian Society of Cardiology (2020) and the European Society of Cardiology (2021).All patients underwent molecular genetic testing of single nucleotide polymorphisms - rs632793 of the NPPB gene, rs5065 of the NPPA gene. The study was performed in accordance with the standards of Good clinical practice (GoodClinicalPractice) and the principles of the Helsinki Declaration. Statistical analysis of the data was carried out using the Microsoft Exel 2016 and Statistica 12.0 software package. The critical level of significance when testing statistical hypotheses was assumed to be 0.05.

Análisis de los datos
When analyzing the frequency of genotypes of single nucleotide polymorphisms (ONP) rs632793 of the NPPB gene and rs5065 of the NPPA gene, taking into account gender, no significant differences were found. When assessing the frequency of the studied genotypes and calculating the odds ratio (OR) in the group of patients with CHF and AF and in the group of patients with CHF without AF, without separation and with gender separation among men, there was a tendency for the relationship of the genotype A/G polymorphism rs5065 of the NPPA gene (OR 2,500; 95% CI: 0.467–13.393, p = 0.28) and genotype T/C polymorphism rs632793 of the NPPB gene (OR 2,100; 95% CI: 0.414–10.664; p = 0.37) with AF in CHF. When assessing the frequency of genotypes and calculating the OR polymorphisms rs632793 of the NPPB gene and rs5065 of the NPPA gene among women, a statistically significant relationship was established between the genotype T/C polymorphism rs632793 of the NPPB gene with AF in CHF (OR 6,600; 95% CI: 1,229–35,439; p = 0.02). There was also a tendency to correlate the A/G rs5065 genotype with AF in CHF (OR 2.037; 95% CI: 0.379–10.938; p = 0.40.

Conclusiones
The results obtained can be used as a basis for conducting multicenter clinical trials to determine highly specific markers of chronic heart failure and atrial fibrillation.